WP 4
WP4 Intervention & Product development
In WP4, advanced laboratory research is combined with practical food interventions to explore and counteract the effects of chronodisruption on obesity.
Intervention - in vitro
- Identify novel biomarkers for obesity during chronodisruption
Normal weight & obese enteroids:
- RNA sequencing
- to study loss or shifts in the rhythmic gut transcriptome
- Organ-on-a-chip based barrier integrity assays to determine
- intestinal rhythmicity disruptions
- identification of microbial metabolites
- chronobiotics that affect rhythmicity in gut epithelial homeostasis during chronodisruption
Intervention - in vivo
- Food intervention study in night shift workers → See the graphic below for a visual summary!
